Table 2 Most significant CpG sites associated with AF (FDR < 0.05).
From: Methylome-wide Association Study of Atrial Fibrillation in Framingham Heart Study
Type | CpG site | Chr | Position + | Closest gene | Distance | Effect size | SE* | P value | FDR* |
|---|---|---|---|---|---|---|---|---|---|
Prevalent AF | cg13639451 | 17 | 48911157 | WFIKKN2 | 1447 bp | −0.010 | 0.002 | 1.1 × 10−7 | 0.030 |
cg07191189 | 2 | 37193690 | STRN | 75 bp | 0.011 | 0.002 | 1.4 × 10−7 | 0.030 | |
Incident AF | cg26602477 | 1 | 1476845 | SSU72 | 207 bp | −8.289 | 1.415 | 4.7 × 10−9 | 0.001 |
cg15440392 | 20 | 36156634 | BLCAP | 301 bp | 4.808 | 0.823 | 5.1 × 10−9 | 0.001 | |
cg04064828 | 10 | 134002751 | DPYSL4 | 0 | −28.669 | 5.218 | 3.9 × 10−8 | 0.006 | |
cg27529934 | 1 | 205054684 | RBBP5 | 585 bp | −8.291 | 1.542 | 7.5 × 10−8 | 0.008 | |
cg06725760 | 10 | 1102461 | WDR37 | 314 bp | 6.655 | 1.300 | 3.1 × 10−7 | 0.027 |
