Table 3 Association of AF-specific CpG sites with the most significant cis-gene expression and trans-gene expression.
From: Methylome-wide Association Study of Atrial Fibrillation in Framingham Heart Study
Type | CpG site | Most significant cis-gene for each AF-related CpG site | Most significant trans-gene for each AF-related CpG site | ||||||
|---|---|---|---|---|---|---|---|---|---|
Gene | Effect size | SE | P value | Gene+ | Effect size | SE | P value | ||
Prevalent AF | cg13639451 | HILS1 | 0.36 | 0.14 | 9.1 × 10−3 | RPS18 | 1.85 | 0.20 | 4.5 × 10−20 |
cg07191189 | STRN | 0.35 | 0.12 | 4.8 × 10−3 | LGSN | 0.77 | 0.18 | 2.3 × 10−5 | |
Incident AF | cg26602477 | C1orf159 | −0.35 | 0.16 | 3.1 × 10−2 | PTPN2 | −1.37 | 0.31 | 1.2 × 10−5 |
cg15440392 | RPN2 | 0.21 | 0.12 | 7.8 × 10−2 | GZMH | −2.18 | 0.37 | 7.0 × 10−9 | |
cg04064828 | DPYSL4 | 0.56 | 0.23 | 1.7 × 10−2 | ABCA4 | −0.98 | 0.20 | 7.9 × 10−7 | |
cg27529934 | PLEKHA6 | 0.26 | 0.09 | 5.6 × 10−3 | ADAMTS2 | 0.40 | 0.09 | 1.3 × 10−5 | |
cg06725760 | ZMYND11 | −0.22 | 0.21 | 2.8 × 10−1 | GZMH | −3.01 | 0.72 | 3.2 × 10−5 | |
