Figure 2: Effect of Tan IIA on the tumor growth and major organs in NOD-SCID mice with or without143B transplants. | Scientific Reports

Figure 2: Effect of Tan IIA on the tumor growth and major organs in NOD-SCID mice with or without143B transplants.

From: Tanshinone IIA induces intrinsic apoptosis in osteosarcoma cells both in vivo and in vitro associated with mitochondrial dysfunction

Figure 2

The tumor mass was dissected from each mouse 45 days after the implantation and weighed. Tan IIA (20 mg/kg) inhibited tumor growth measured in solid tumors (a), tumor weight (b) as well as tumor volume (c). Histopathologic analysis of the tumors (d) and major organs including heart, liver, spleen, lungs and kidneys (e) in Tan IIA group compared to those in the control group by Hematoxylin and Eosin stain, original magnification ×200. (f) The organ weight had no significant differences between Tan IIA-treated and non-treated groups. Arrows indicates osteosarcoma. Values are mean ± SD (n=15). An asterisk demonstrates the significant difference (p < 0.05) between control and Tan IIA-treated groups.

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