Figure 3: MiRNA-488 directly targeted eIF3a. | Scientific Reports

Figure 3: MiRNA-488 directly targeted eIF3a.

From: MiR-488 inhibits proliferation and cisplatin sensibility in non-small-cell lung cancer (NSCLC) cells by activating the eIF3a-mediated NER signaling pathway

Figure 3

(a) The pmiR-RB-REPORT™ (vector) containing wild-type or mutant eIF3a 3’UTRs was constructed using the matching seed sequence of miR-488 and eIF3a. (b) The relative luciferase activity of the indicated eIF3a reporter construct was analyzed in A549 cells. The Renilla luciferase activity of each sample was normalized to the firefly luciferase value and plotted as relative luciferase activity.

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