Figure 5: MiR-218 regulates synaptic plasticity-related genes.
From: MiR-218 targets MeCP2 and inhibits heroin seeking behavior
(a) MirSystem analysis of miR-218 target genes revealed significant enrichment in neuronal plasticity-related pathways. (c) Relative expression level of Gabrb3, GluR2, Dnmt3a, Ube3a, Nrxn1, Sema6b, Gng3 and Mecp2 in NAc of rats treated with saline or chronic heroin (1 mg/kg, i.p., b.i.d, CS, Chronic Saline, n = 10; CH, Chronic Heroin, n = 6; Student’s t-test *P < 0.05, **P < 0.01). Data are shown as mean ± s.e.m.
