Figure 2: IRSp53 deletion results in defective cardiac development. | Scientific Reports

Figure 2: IRSp53 deletion results in defective cardiac development.

From: Redundant functions of I-BAR family members, IRSp53 and IRTKS, are essential for embryonic development

Figure 2

(A) Histological analysis of sagittal sections of E10.5 embryonic heart in IRSp53+/− and IRSp53−/− embryos. Lower panels show the atrioventricular (AV) cushions at higher magnification. Hypocellular AV cushions (arrowheads) and detachment of endocardium from the myocardium (arrows) were observed in the IRSp53−/− embryos. A, atrium, V, ventricle. Scale: 100 μm. (B) E14.5 hearts dissected from heterozygous and null embryos. Misshapened right ventricles were noted in IRSp53−/− hearts (arrowheads). (C) Histology of E14.5 heterozygous and null hearts. H&E of transverse heart sections (left panels) revealed defects in the interventricular septum (middle panels, arrowhead), thin ventricular walls (right panels) and detachment of the epicardium from the myocardium (arrow) in IRSp53−/− embryos. RV, LV: right, left ventricle. Scale: 200 μm.

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