Figure 5: HE examination of repaired regions.

Repaired tissues in the 2-week and blank groups showed signs of fibrogenesis and partial ossification with clear interface to the native tissue. Repaired tissues in the 4- and 8-week groups were primarily composed of cartilage- and bone-like tissues. Newly formed cartilage in these two groups exhibited a higher cell density than the surrounding native cartilage, with mature lacuna structures and satisfactory interface integration of both cartilage and osteochondral interfaces. NA: native area; IF: interface; RA: repaired area; SB: subchondral bone. Black arrows indicate repaired regions.