Figure 2: Conditional knockout PKD1 in vivo with Osx::PKD1fl/fl mice caused postnatal growth defects. | Scientific Reports

Figure 2: Conditional knockout PKD1 in vivo with Osx::PKD1fl/fl mice caused postnatal growth defects.

From: A Conditional Knockout Mouse Model Reveals a Critical Role of PKD1 in Osteoblast Differentiation and Bone Development

Figure 2

(a) Photographic appearance of the 4-week-old WT and KO mice. KO mice were smaller than control mice at 4 weeks. (b) Picture of hind limbs from the 4-week-old WT and KO mice. (c,d) The length changes of femur and tibia from hind limb of 4-week-old and 10 weeks of WT or KO mice. Measurements were presented as mean ± SD (n ≥ 7). The data in each group was analyzed using unpaired, two-tailed Student’s t-test. The level of significance was set at *p < 0.05. (e) Whole-mount skeletal was stained by Alizarin red and Alcian blue staining of 14-day-old of WT or KO mice. (f) Alcian blue/Alizarin red staining of skulls from WT and KO mice (green arrows showed undeveloped skull). (g) Alcian blue/Alizarin red staining of lone bone from WT and KO mice. The arrow reviewed abnormal nodules in scapula.

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