Figure 3: Bone mass was reduced in the distal femur of PKD1 KO mice by micro-CT analysis. | Scientific Reports

Figure 3: Bone mass was reduced in the distal femur of PKD1 KO mice by micro-CT analysis.

From: A Conditional Knockout Mouse Model Reveals a Critical Role of PKD1 in Osteoblast Differentiation and Bone Development

Figure 3

(a) Less difference of bone mass between WT and KO mice by representative micro-CT images of the distal femur (upper panel) and the structure of metaphyseal (lower panel) trabecular bone. (b) Micro-CT images of cortical bone in the mid-diaphysis (upper panel) and trabecular bone in the metaphysis (middle and lower panel). (c) Three-dimensional models images of micro-CT analyses of the structure of metaphyseal trabecular bone and cortical bone in the distal femur. (d,e) Quantitative micro-CT analyses of cortical and trabecular structure at the distal femur. Measurements were trabecular number (Tb.N), trabecular thickness (Tb.Th), trabecular (Tb) tissue volume (TV), bone volume (BV) and bone volume fraction (BV/TV), trabecular separation (Tb.Sp), bone mineral density (Tb.BMD), cotircal bone mineral density (Ct.BMD) and Cortical thickness (Ct.Th) (n = 3), WT or KO mice at 4 weeks old. Measurements are presented as mean ± SD. *p < 0.05 versus respective control.

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