Figure 10: SOCS1 regulates the expression of BMPR1 and TGF-beta/BMP signaling pathways. | Scientific Reports

Figure 10: SOCS1 regulates the expression of BMPR1 and TGF-beta/BMP signaling pathways.

From: SOCS1 favors the epithelial-mesenchymal transition in melanoma, promotes tumor progression and prevents antitumor immunity by PD-L1 expression

Figure 10

Western blottings of whole cell lysates (30 μg of protein) from B16F10-Nex2 control cells (treated with empty lentivirus vector) (lane 1) and B16shR-SOCS1 silenced strain (lane 2). (A) SOCS1-silencing enhanced BMPR1 expression, and (B) enhanced total Smad 2/3, p-Smad 2/3, total Smad 1/5/8 and p-Smad 1/5/8. Silencing of SOCS1 did not alter the expression of Smad 4. A representative blot from three independent experiments is shown for each panel. *Results were normalized by β-actin.

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