Figure 6: MP plays a tumorsuppressor role and antagonizes ROK in HCC. | Scientific Reports

Figure 6: MP plays a tumorsuppressor role and antagonizes ROK in HCC.

From: Myosin phosphatase and RhoA-activated kinase modulate arginine methylation by the regulation of protein arginine methyltransferase 5 in hepatocellular carcinoma cells

Figure 6

We hypothesize that MP and ROK are involved in gene expression. Under normal conditions MP modulates symmetrical dimethylation of histone core proteins in cell nucleus via dephosphorylation of PRMT5 at its activatory phosphorylation site (Thr80) causing changes in gene expression. In tumor cells inhibitory phosphorylation of MP on Thr850 is increased leading to higher phosphorylation level of PRMT5 at Thr80 by ROK. Activated PRMT5 provokes gene repression by raising symmetrical dimethylation of histone H4 Arg3 that triggers proto-oncogene activation and tumor formation.

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