Figure 4: Gene ontology analysis of the vitamin-induced transcriptional changes during infection.

Analysis revealed the Immune System Process as the most affected GO category in response to vitamin treatment. (A) GO enrichment analysis of all atRA-regulated genes (1573 genes, FC > 2, p < 0.05) during any of the three analysed infections. Percentage of the total enrichment scores are shown for the top five GO categories (biological process). (B) GO enrichment analysis of all vitD-regulated genes (624 genes, FC > 2, p < 0.05) during any of the three analysed infections. (C) Top atRA-regulated GO categories during each of the infections. (D) Top vitD-regulated GO categories during each of the infections.