Figure 7: Immunomodulatory footprint of vitamin D during infection. | Scientific Reports

Figure 7: Immunomodulatory footprint of vitamin D during infection.

From: Differential Effects of Vitamins A and D on the Transcriptional Landscape of Human Monocytes during Infection

Figure 7

VitD shows a pathogen-specific regulatory role on immune-relevant genes leading to an overall down-regulation of cytokines, chemokines and matrix metalloproteases. (A) Venn diagram showing the overlap and amount of vitD-regulated immune-relevant genes (GO:0002376) in each of the infections analysed: A. fumigatus (blue), C. albicans (green) and E. coli (magenta). (B) Network based on experimental and database-derived knowledge (edges) generated with the STRING database. ○ vitD regulated these genes in at least two of the pathogenic infection settings; vitD-regulated genes during C. albicans infection; □ vitD-regulated genes during E. coli infection; vitD-regulated genes during A. fumigatus infection; red: down-regulation, green: up-regulation.

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