Table 1 Model input parameters (Vmax and Km) for L-leucine and L-phenylalanine transporters.
From: Quantifying the relative contributions of different solute carriers to aggregate substrate transport
Symporters | Antiporters | Uniporters | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
SLC no. | SLC6A14 | SLC6A19 | SLC7A5 | SLC7A8 | SLC7A7 | SLC7A6 | SLC1A5 | SLC16A10 | SLC43A1 | SLC43A2 | ||
Alias | ATB0,+ | B0 AT1 | LAT1 | LAT2 | y+LAT1 | y+LAT2 | ASCT2 | TAT1 | LAT3 | LAT4 | ||
Accessory protein | Â | coll TMEM27 | 4F2hc SLC3A2 | 4F2hc SLC3A2 | 4F2hc SLC3A2 | 4F2hc SLC3A2 | Â | Â | Â | Â | ||
Vmax (nmol/h) | ||||||||||||
| Â | Â | Â | Â | Â | Â | Â | Â | Â | Vmax1 | Vmax2 | Vmax1 | Vmax2 |
Leu | 0.014a46 | 0.53920 | 0.16247 | 0.40248 | 0.3849 | 1.6050 | 1.0151 | NA | 0.013817 | 0.76617 | 0.020418 | 3.51618 |
Phe | 0.034a46 | 1.11820 | 0.14747 | 0.2748 | NA | NA | NA | 10027 | 0.007617 | 0.7517 | 0.020418 | 3.51618 |
Km(mM) | ||||||||||||
| Â | Â | Â | Â | Â | Â | Â | Â | Â | Km1 | Km2 | Km1 | Km2 |
Leu | 0.01252 | 1.153 | 0.03254 | 0.04855 | 0.031749 | 0.23650 | 0.36751 | NA | 0.084217 | 1.02417 | 0.10318 | 3.73318 |
Phe | 0.01752 | 4.753 | 0.7454 | 0.012255 | NA | NA | NA | 3627 | 0.065817 | 1.20617 | 0.17818 | 4.69418 |
Ala | 0.09952 | 4.153 | NA | 0.16755 | NA | 4.1250 | 0.018451 | NA | NA | NA | NA | NA |
Arg | 0.10452 | NA | NA | NA | 0.3449 | 0.17750 | NA | NA | NA | NA | NA | NA |
Trp | 0.02652 | >1253 | 0.021447 | 0.057648 | NA | NA | NA | NA | NA | NA | NA | NA |
BCH | 0.52a52 | NA | 0.05556 | 0.02356 | NA | NA | NA | NA | 0.055b56 | 2.5ab17 | 0.055b56 | 28ab17 |
Val | 0.03652 | 1.53a20 | 0.047247 | 0.12448 | NA | NA | 0.52251 | NA | 0.030617 | 1.88517 | 0.0472b56 | 36ab17 |
Sodium dependent | yes | yes | no | no | yes | yes | yes | no | no | no | ||
Log 10 mRNA | 4 | 0.6 | 1 | 2.5 | 3.4 | 3 | 3.5 | 0.8 | 2.4 | 1.5 | ||
