Figure 8: Summary model of the role of IL-4 signaling in HD-DC suppression of colitis. | Scientific Reports

Figure 8: Summary model of the role of IL-4 signaling in HD-DC suppression of colitis.

From: Suppression of colitis by adoptive transfer of helminth antigen-treated dendritic cells requires interleukin-4 receptor-α signaling

Figure 8

Recipient IL-4Rα signaling is required for HD-DC induction of IL-4, and suppression of colitis. HD-DCs induce IL-4 production in recipients, which likely enhances recipient IL-4 production via autocrine signaling through IL-4Rα. Activation of IL-4Rα is required to drive the regulatory anti-colitic phenotype of HD-DCs, in addition to splenic IL-4 and IL-10 in recipient mice. As HD-DCs are not a source of IL-4, HD-DC induced recipient IL-4 is the likely source for IL-4Rα activation on HD-DCs. HD-DCs produce IL-10 in vivo, and drive synthesis of IL-4 and IL-10 in recipient mice. Overall, IL-10 is an anti-colitic cytokine that can suppress TH1 and TH17 pro-inflammatory responses, and is required to establish Th2 immune responses; IL-4 is also anti-colitic, driving TH2 and suppressing TH1 immune responses, driving the alternative activation of macrophages, and enhancing mucus production.

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