Figure 7: Conservation of coiled-coil interaction.
From: Methylation specific targeting of a chromatin remodeling complex from sponges to humans
(a) Synonymous and non-synonyous codon variation across all MBD2/3 and GATAD2A/B coiled-coil domains are plotted against the human sequences. (b) Codon selection is mapped onto the solution structure of the MBD2:GATAD2A coiled coil complex. Conserved residues are shown as sticks and color coded for codon selection. (c) Average helical propensity for the coiled-coil domains, as determined by the Agadir algorithm, is plotted for vertebrate and invertebrate MBD2/3 and GATAD2A/B orthologs.
