Figure 1: Prolongation of corrected QT interval and action potential duration in UNx rats.
From: Electronegative LDL-mediated cardiac electrical remodeling in a rat model of chronic kidney disease
(a) Representative electrocardiogram recordings of sham and UNx rats. (b) Superimposed action potentials of epicardial (left panel) and endocardial (right panel) cardiomyocytes from sham and UNx rats. The horizontal line indicates zero voltage level. (c) Comparison of the action potential duration at 25% (APD25), 50% (APD50), and 90% (APD90) repolarization in epicardial and endocardial cardiomyocytes from both sham and UNx rats. (d) Comparison of the action potential amplitude (APA) and the resting membrane potential (RMP) in epicardial and endocardial cardiomyocytes from both sham and UNx rats. n = 10 from 6 animals per group. *P < 0.05, ***P < 0.01 vs. sham group.
