Figure 4: Electronegativity of LDL isolated from UNx rats and its effects on action potential.
From: Electronegative LDL-mediated cardiac electrical remodeling in a rat model of chronic kidney disease
(a) Representative agarose gel electrophoresis of LDL isolated from UNx and sham rats. (b) Superimposed action potentials of normal epicardial (left panel) and endocardial (right panel) cardiomyocytes treated with 100 μg/mL sham LDL and UNx rat LDL. The horizontal line indicates zero voltage level. (c) Comparison of the action potential duration at 25% (APD25), 50% (APD50) and 90% (APD90) repolarization in epicardial and endocardial cardiomyocytes treated with sham LDL and UNx LDL. (d) Comparison of the action potential amplitude (APA) and resting membrane potential (RMP) in epicardial and endocardial cardiomyocytes treated with sham LDL and UNx LDL. n = 6 from 4 animals per group. **P < 0.01, ***P < 0.001 vs. sham LDL group.
