Figure 5: Disruption of transmural gradient of Ito in ventricular myocytes treated with UNx rat LDL.
From: Electronegative LDL-mediated cardiac electrical remodeling in a rat model of chronic kidney disease
(a) The original superimposed recordings of outward K+ current of normal epicardial (left panel) and endocardial (right panel) cardiomyocytes treated with 100 μg/mL sham and UNx rat LDL. The arrow in each panel indicates zero current level. (b) Schematic diagram of the voltage clamp protocol. (c) Comparison of the I-V relationships of transient outward current (Ito) in epicardial cardiomyocytes treated with sham and UNx rat LDL. *P < 0.05 vs. sham LDL group. (d) Comparison of the I-V relationships of transient outward current (Ito) in endocardial cardiomyocytes treated with sham and UNx rat LDL. (e) The difference between the mean epicardial (EPI) and endocardial (ENDO) Ito current of sham and UNx rat LDL-treated cardiomyocytes is plotted as the transmural gradient of Ito. n = 7 from 5 animals per group. *P < 0.05 vs sham LDL group, two-way ANOVA with the post-hoc Bonferroni correction.
