Table 2 Second screening results in male trap lines.

From: Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models

No	Gene Symbol	Genotype	Growth Curve	Blood Test	Bone X-gal Staining	Bone Morphometric Analysis
						BMD Analysis				Cortical Bone Analysis			Trabecular Bone Analysis				Biomechanical Strength Analysis
						Tb.BMD	Tb.BMC	Ct.BMD	Ct.BMC	Ct.V	Ct.Th	Ex.Ln.Le	BV	Tb.Th	Tb.N	V*m.space	M.load	M.stress	M.dsp	M.work	E.M.
1	Bptf	WT/Het	↓	+	+			↓	↓	↓		↓									↓
2	New	WT/Hom			+													↑
3	New	WT/Hom				↑			↓	↓		↓	↓	↓	↓	↑
4	EST	WT/Hom	↑	+			↑						↑					↓		↑
5	Apobec1	WT/Hom		+	+			↓								↑		↓
6	Reep3	WT/Hom		+													↑			↑
7	Trp53cor1	WT/Hom	↑	+
8	Lpar5	WT/Hom	↓	+
9	Ankrd11	WT/Het		+	+											↑
10	Lima1	WT/Hom	↓	+		↓	↓	↓	↓	↓	↓	↓	↓	↓		↑	↓			↓
11	Cnn3	WT/Het		+	+						↑
12	Wdr11	WT/Hom	↓		+															↓
13	Tctn1	WT/Het			+		↑						↑		↑				↓
14	2500002B13 Rik; lincRNA	WT/Hom		+	+				↑	↑	↑
15	EST	WT/Hom		+
16	Msi2	WT/Hom	↓	+	+	↓	↓		↓	↓		↓	↓	↓	↓	↑	↓		↓	↓	↓
17	Wdfy1	WT/Hom	↓		+											↑			↑
18	Nedd4	WT/Het	↓	+	+				↓	↓
19	Tmem161a	WT/Hom	↑		+						↑						↑	↑
20	Mark3	WT/Het	↓	+	+						↓					↑
21	Cyb5b	WT/Het		+
22	EST	WT/Hom	↓	+				↓					↓
23	Pkig	WT/Hom	↑	+	+		↑		↑	↑		↑	↑	↑	↑				↑	↑
24	Brd1	WT/Het	↓	+	+			↓
25	Fbxo17	WT/Hom		+																↑
26	4933407K13 Rik; uncRNA	WT/Het		+
27	Epb4.1l2	WT/Hom	↓	+	+							↓					↓				↓
28	New	WT/Hom			+
29	Cirh1a	WT/Het		+
30	New	WT/Hom	↓	+	+	↑	↑			↑		↑	↑	↑	↑		↑			↑	↑
31	Etf1	WT/Het		+	+			↓			↓								↑		↓
32	Ywhag	WT/Het		+	+
33	Hdac4	WT/Het	↓													↓
34	Lbr	WT/Hom	↓	+	+	↓	↓		↓	↓		↓		↓		↑	↓	↓			↓
35	Umps	WT/Het			+											↑
36	Rcl1	WT/Het			+										↑
37	1600020E01 Rik; lincRNA	WT/Het		+	+							↑				↑					↑
38	Dym	WT/Hom		+	+				↓	↓								↓			↓
39	Ptpn11	WT/Het	↑	+	+								↑		↑	↓		↓			↑
40	Slc38a2	WT/Hom	↓	+	+						↓										↓
41	Ndufaf1	WT/Het	↑	+				↓			↓								↓	↓
42	D19Wsu162e	WT/Hom	↓	+	+
43	Ppat	WT/Het	↓	+	+			↑
44	Slc38a4	WT/Het	↓	+	+														↓	↓
45	EST	WT/Het	↓	+	+							↓		↑				↑
46	P4hb	WT/Hom	↓	+	+		↓		↓	↓		↓	↓	↓	↓	↑	↓
47	Osbpl8	WT/Hom	↓		+		↑				↓		↑	↑	↑		↓			↓
48	Rbm12	WT/Hom		+	+								↓
49	Itpr1	WT/Het	↓		+						↓			↓
50	Ctnnd1	WT/Het	↓	+	+														↑
51	Srr	WT/Hom	↓													↑		↓			↓
52	RhoA	WT/Het

WT: wild-type, Het: Heterozygote, Hom: Homozygote, Tb.BMD: trabecular bone mineral density, Tb.BMC: trabecular bone mineral content, Ct.BMD: cortical bone mineral density, Ct.BMC: cortical bone mineral content, Ct.V: cortical bone volume, Ct.Th: cortical bone thickness, Ex.Ln.Le: external line length, BV: trabecular bone volume, Tb.Th: trabecular bone thickness, Tb.N: trabecular bone number, V*m.space: marrow space star volume, M.load: maximum load, M.stress: maximum stress, M.dsp: maximum displacement, M.work: maximum work, E.M: elastic modulus. +: abnormal blood test results, positive X-gal staining, ↑: > [WT mean + 2.0 SD], ↓: < [WT mean − 2.0 SD], “R” line has not been registered with the EGTC database.

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Table 2 Second screening results in male trap lines.

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