Figure 1: UV absorption spectra of Chelerythrine (10 μM) with increasing concentration of promoter sequences (BCL2, KRAS and VEGFA) showing red shift and hypochromism. | Scientific Reports

Figure 1: UV absorption spectra of Chelerythrine (10 μM) with increasing concentration of promoter sequences (BCL2, KRAS and VEGFA) showing red shift and hypochromism.

From: Chelerythrine down regulates expression of VEGFA, BCL2 and KRAS by arresting G-Quadruplex structures at their promoter regions

Figure 1

(B) BCL2 (12 nm red shift, hypochromism 61%), (C) KRAS (14 nm red shift, hypochromism 50%), (D) VEGFA (12 nm red shift, hypochromism 63%). All experiments were carried out using 10 mM potassium phosphate buffer containing 100 mM potassium chloride at pH 7.0. (A) Chemical structure of Chelerythrine.

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