Figure 6: Isothermal titration calorimetry (ITC) profile of Chelerythrine with promoter sequences (BCL2, KRAS and VEGFA). | Scientific Reports

Figure 6: Isothermal titration calorimetry (ITC) profile of Chelerythrine with promoter sequences (BCL2, KRAS and VEGFA).

From: Chelerythrine down regulates expression of VEGFA, BCL2 and KRAS by arresting G-Quadruplex structures at their promoter regions

Figure 6

(A) BCL2 (B) KRAS (C) VEGFA. The top panel display the isothermal plot of the Chelerythrine-promoter sequences complex formation, whereas lower panel represent the integrated binding isotherm generated from the integration of peak area as a function of molar ratio. The solid line represents the best fit data using ‘one site binding model’.

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