Figure 2: Genome wide integrative analysis of gene overexpression, DNA copy number gain and promoter DNA hypomethylation in esophageal adenocarcinoma. | Scientific Reports

Figure 2: Genome wide integrative analysis of gene overexpression, DNA copy number gain and promoter DNA hypomethylation in esophageal adenocarcinoma.

From: Integrated molecular analysis reveals complex interactions between genomic and epigenomic alterations in esophageal adenocarcinomas

Figure 2

Circos plots that demonstrate the gene expression vs copy number that have the same directional changes. Gene expression and copy numbers vs methylation have opposite direction changes. Some high-level gene amplifications were shown in some chromosomes, such as 5, 6, 7, 11, 15, and 22. DNA hypomethylation is wide across the whole genome and denser in chromosome 1, 2, 3, 7, 8, 12 and X. Data shows the complexity of gene regulation through genetic and epigenetic mechanisms.

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