Table 2 Upstream Activated Molecular Pathways.
Upstream Regulator | P value of overlap | Target molecules in dataset |
|---|---|---|
Transcription Factor | ||
CEBPB | 8.55E-07 | ALDH1A1, CFTR, COL10A1, COL1A2, COL5A2, CXCL8, DAB2, DHRS1, LYN, MGP, MMP1, MMP10, MMP3, NDRG4, NFATC2, PCK1, PPARG, PTGS2, SEMA3E, SGK1, SIM2, SPP1, TNFAIP6, VLDLR |
CTNNB1 | 4.81E-05 | ALDH1A1, ALDH3A2, BMP2, COL4A1, COL4A2, CXCL8, GHR, HSD17B2, ITGB7, MME, MMP1, MMP3, MMP7, NDRG2, NOTCH3, PTGS2, RAI14, SDC2, SEMA3C, SGK1, SIM2, SLC6A1, SPP1, TCF7L2, TNFRSF11B, TNIK, TSPAN8, VCAM1, WNT4 |
CEBPA | 6.32E-05 | ADH6, CCL20, COL10A1, COL1A2, CXCL8, EVPL, GATA6, GRHL3, NFATC2, OLR1, OVOL1, PCK1, PGD, PPARG, PPL, PTGS2, SEMA3E, SPP1, TIAM1, TNFAIP6, VLDLR |
MYB | 2.81E-04 | ATP2B1, COL1A2, FUT8, MMP1, MMP3, NMU, PTGS2, SPP1 |
PPRC1 | 1.70E-03 | CCL20, CXCL8, LAMB3, PTGS2, SPINK1 |
HMGB1 | 3.08E-03 | CCL20, CXCL8, MMP1, MMP3, PTGS2, VCAM1 |
SOX7 | 7.91E-03 | EVPL, GRHL3, OVOL1, PPL |
TWIST1 | 8.21E-03 | ALDH1A1, CXCL8, ETS1, FGFR3, MME, MMP1, PXDN, SPP1 |
PAX1 | 1.18E-02 | EVPL, GRHL3, OVOL1, PPL |
GATA6 | 2.13E-02 | DAB2, EVPL, GRHL3, LTBP1, OVOL1, PPL, SEMA3C |
GATA3 | 7.64E-02 | ETS1, EVPL, FOXE1, GRHL3, OVOL1, PPARG, PPL |
ETS1 | 2.12E-01 | COL1A2, ETS1, MMP1, MMP3, MMP7, SPP1 |
Growth Factor | ||
TGFB1 | 1.40E-12 | ABLIM3, ACVR1, ADAMTS12, AHNAK, ALDH3A2, ALOX12, ANXA8/ANXA8L1, AQP9, ASPN, BMP2, BUB1, CALB2, CCL20, CELSR2, CNN3, COL12A1, COL1A2, COL3A1, COL4A1, COL4A2, COL6A3, CXCL8, DAB2, DACH1, DLX5, DSP, ESPL1, ESRP2, ETS1, FAP, FNDC3B, FUT8, GGT6, GPR158, HLTF, INHBA, ITGA11, ITGAV, ITGB7, KCNJ3, KDELR3, LAMB3, LIFR, LTBP1, MGP, MMP1, MMP10, MMP12, MMP3, MMP7, NDRG4, NDST1, NFATC2, NOTCH3, OLR1, OVOL1, PLCB1, PMEPA1, PMM1, POSTN, PPARG, PTGS2, PTPRK, RAD51AP1, RARG, SGK1, SHMT1, SPP1, TNFAIP6, TNFRSF11B, TXNRD1, VAT1, VCAM1, WNT4, WNT5A |
TGFB3 | 6.55E-07 | ASPN, CDH6, COL1A2, COL3A1, ETS1, ITGAV, MGP, MICAL2, MMP1, MMP10, MMP3, TNFRSF11B |
AGT | 1.29E-06 | ALOX12, ATP2B1, COL1A2, COL3A1, COL4A1, CXCL8, DAB2, ETS1, GATA6, ITGAV, ITGB7, MAPT, NOTCH3, OLR1, PDE3A, POSTN, PPARG, PTGS2, SGK1, SLC10A6, SPP1, STC1, TFPI, VCAM1, WNK4 |
HGF | 3.75E-06 | BMP2, BUB1, COL1A2, COL3A1, COL4A1, CXCL8, EMP2, ETS1, FNDC3A, GRB10, HK1, INHBA, LY75, MMP1, PRKAA1, PTGS2, PTPRR, SGK1, SLC9A3R1, SPP1, STC1, TMEM97, TNFAIP6, TRIP10, TRIP13, VCAM1 |
BTC | 6.01E-05 | CCL20, CXCL8, PTGS2, TNFAIP6 |
ANGPT2 | 8.37E-05 | COL1A2, COL3A1, ETS1, GATA6, LYN, MMP1, MMP7, OLR1, POSTN, PTGS2, TLR3, TNIK, VCAM1 |
JAG1 | 1.79E-04 | ITGAV, PTPRK, RNF128, SPP1, WNT4 |
VEGFA | 3.91E-04 | ACADM, CSTB, CXCL8, ETS1, ETV5, GRB10, HK1, MMP1, MMP12, PTGS2, STC1, TSPO, VCAM1 |
EGF | 1.25E-03 | ALOX12, AQP3, CCL20, COL1A2, COL3A1, CXCL8, DPP4, ETS1, FUT3, INHBA, MMP1, MMP10, MMP12, MMP3, PDE3A, PER1, PPARG, PTGS2, SPP1, VCAM1 |
Kinase | ||
ERBB2 | 1.14E-08 | AHNAK, ANG, BNIP3, BUB1, C4BPB, CCL20, COL3A1, COL4A1, COL5A2, COL6A3, CXCL8, DAP, EPSTI1, ESPL1, ETV5, FAM134B, GHR, HEPH, LPCAT1, LUM, MME, MMP1, MMP10, MMP12, MMP3, MMP7, NDRG4, NDST1, NOTCH3, PMEPA1, PPARG, PTGS2, PTPRK, RAD51AP1, TFAP2C, WNT5A |
FGFR2 | 1.57E-05 | COL4A1, COL4A2, DAB2, GATA6, GPT2, GRB10, NOSTRIN, SPINK1, SPP1, TSPAN8, VCAM1 |
RET | 5.93E-05 | CCL20, COL1A2, CXCL8, HSPH1, MMP1, MMP10, MMP3, MMP7, PTPN13, STC1 |
CHUK | 1.63E-04 | BMP2, CXCL8, GM2A, LIFR, MGP, MMP3, OVOL1, PTGS2, SEMA3C, SGK1, SPP1, TNFRSF11B, VCAM1 |
PIK3R1 | 1.59E-03 | COL1A2, CXCL8, PCK1, PPARG, PTGS2, VCAM1 |
MAP3K1 | 3.82E-03 | COL3A1, COL4A1, CXCL8, MMP3, PTGS2 |
MAPK8 | 2.68E-02 | CXCL8, ETS1, MMP1, MMP3, PTGS2, WNT4, WNT5A |
MAPK1 | 1.13E-01 | CPPED1, CXCL8, DAB2, ITGAV, LAMA4, MMP1, PTGS2, PTPRK, SPP1, TLR3 |
Cytokine | ||
OSM | 7.79E-10 | AQP9, C4BPA, CALB2, CASK, CCL20, CDA, CLIP1, COL3A1, CXCL8, DHCR24, EPHA1, EVPL, FMO5, LIFR, MGLL, MMP1, MMP10, MMP3, NOTCH3, PPARG, RARG, SCNN1B, SLC7A8, SULT2B1, TDO2, TECR, TLR3, TNFRSF11B, TYRO3, UBE2G1, UPK1A, USP46, VCAM1, WNT5A |
IL1A | 1.79E-07 | ALDH1A1, ALDH3A2, CCL20, CXCL8, DPP4, INHBA, ITGAV, MMP1, MMP10, MMP12, MMP3, PPARG, PTGS2, SPP1, TICAM1, TNFRSF11B, VCAM1, WNT5A |
TNF | 1.51E-06 | ACADM, ALOX15B, AQP3, AQP9, ATP2B1, BCKDHA, BMP2, CCL20, CFTR, COL1A2, COL3A1, CXCL8, DMBT1, DPP4, DSC3, EMP2, ETS1, FOXE1, FUT3, GHR, GM2A, INHBA, ITGAV, ITGB7, LAMA4, LAMB3, LIFR, LYN, MGP, MMP1, MMP10, MMP12, MMP3, MMP7, NFATC2, OLR1, PCK1, POSTN, PPARG, PTGS2, SCNN1B, SCNN1G, SCUBE2, SDC2, SEMA3C, SGK1, SLC7A8, SPP1, SYTL1, TFAP2C, TFPI, TICAM1, TLR3, TNFAIP6, TNFRSF11B, TXNRD1, VCAM1, WNT5A |
IL1B | 2.19E-05 | ALDH7A1, BMP2, CCL20, CFTR, COL10A1, CXCL8, DAB2, DPP4, FGFR3, GHR, GM2A, INHBA, ITGAV, LAMB3, LIFR, MAPT, MMP1, MMP10, MMP12, MMP3, MMP7, OLR1, PLXDC2, POSTN, PPARG, PTGS2, SCNN1B, SCNN1G, SCUBE2, SPP1, SULT1E1, TLR3, TNFAIP6, TNFRSF11B, VCAM1 |
TNFSF11 | 3.33E-05 | AQP9, CLOCK, CXCL8, DAB2, ECT2, ETS1, GRB10, ITGAV, MMP1, NFATC2, PAG1, PTGS2, SPP1, TNFRSF11B, TSPAN5, VCAM1 |
IL17F | 1.79E-04 | CCL20, CXCL8, MMP1, MMP3, PTGS2 |
IL6 | 1.13E-03 | ACVR1, AHNAK, ANG, BMP2, BUB1, CCL20, COL3A1, CXCL8, DLX5, ITGAV, LIFR, MMP1, MMP10, MMP12, MMP3, MMP7, PPARG, PTGS2, REG1A, SGK1, SPP1, TLR3, TNFRSF11B, VCAM1, VLDLR, WNT5A |
TNFSF12 | 1.92E-03 | CXCL8, MMP1, MMP10, MMP12, MMP3, NOTCH3, VCAM1 |
EDN1 | 4.46E-03 | COL1A2, COL4A1, CXCL8, ITGAV, MMP1, MMP3, MMP7, OLR1, PTGS2, VCAM1 |
IL18 | 5.00E-03 | CCL20, CXCL8, MMP1, MMP3, PTGS2, SPP1, TNFRSF11B, VCAM1 |
MIF | 1.14E-02 | CXCL8, MMP1, MMP3, PTGS2, VCAM1 |
CSF2 | 1.37E-02 | BUB1, CXCL8, F2RL2, HSPH1, INHBA, LY75, MME, MMP1, NDST1, NFATC2, PPARG, PTGS2, SGK1, SPP1, TICAM1, TRIP13 |
IL17A | 3.53E-02 | CCL20, CXCL8, MMP1, MMP3, PTGS2, TLR3, TNFRSF11B, VCAM1 |
Enzyme | ||
CD44 | 4.52E-05 | COL3A1, COL5A2, ITGAV, KREMEN1, LTBP1, MMP12, MMP3, MMP7, PMEPA1, SPP1, TIAM1, VCAM1, WNT5A |
PTGS2 | 9.84E-04 | ANG, CXCL8, DLX5, ITGAV, MMP1, MMP7, NEB, PTGS2, STC1, TNFAIP6 |
FN1 | 1.71E-02 | CXCL8, DHCR24, HK1, ITGAV, MGP, MMP1, MMP3, RRAGD, SPP1 |
