Figure 1: Abnormal expression of BORIS in clinical colorectal cancer tissues.
From: Brother of Regulator of Imprinted Sites (BORIS) suppresses apoptosis in colorectal cancer
(a) Data downloaded from Oncomine database were replotted by R.3.2.3 boxplot. The Y axis indicates colorectal tissues. RMA: Rectal mucinous adenocarcinoma (N = 6), RA: rectal adenocarcinoma (N = 60), R: rectum (N = 3), COA: colon adenocarcinoma (N = 102), CMA: colon mucinous adenocarcinoma (N = 20), CEA: cecum adenocarcinoma (N = 24), C: Colon (N = 19). The normal colon and rectal cases were used as controls (defined as h) to calculate the differential expression of BORIS between cancer and normal tissues. The p-values between cancer and normal samples were calculated using the Wilcoxon test and were 0.01186 (h, RMA), 1.017e-09 (h, RA), 1.89e-08 (h, COA), 0.000226 (h, CMA), and 2.897E-06 (h, CEA). (b) Statistical analysis of BORIS intensity difference between cancer and adjacent tissues detected by IHC in 180 FFPE clinical colon tissues. (c) Representative IHC images captured using a 10×objective. (d) Statistical analysis of the difference in the content of BORIS between the cytoplasm and nucleus in clinical colon tissues.
