Figure 6: BNP is regulated by PGC-1α and exercise in muscle in vivo.
From: Paracrine cross-talk between skeletal muscle and macrophages in exercise by PGC-1α-controlled BNP
(A,B) Four hours after i.m. injection of BNP, Pcolce or PBS into TA muscle, mRNA expression of pro- (A) and anti-inflammatory (B) cytokines was determined. (C) Chemokine expression levels were also measured after i.m. injections and were largely increased. (D–F) An exercise test to exhaustion was performed and quadriceps muscle was analyzed immediately (0 h post-exercise) and 4 h post-exercise. Time courses of PGC-1α and BNP (D), chemokines and pro- and anti-inflammatory cytokines (F) expression were determined. Values represent the mean of at least (E) 6 animals +SEM. *P < 0.05; **P < 0.01; ***P < 0.001.
