Figure 7: FP7 treatment protects mice from lethal influenza challenge.

C57BL/6 J mice were infected with mouse-adapted influenza, strain PR8 (~7500 TCID₅₀, i.n.; ~LD90). Two days later, mice received vehicle (saline; i.v.), or FP7 (200 μg/mouse; i.v.) once daily from days 2 to 6 post-infection. (a) Mice were monitored daily for survival for 14 days (5 mice/treatment group) (a). (b) On day 7 post-infection, another group of 5 mice per treatment were euthanized and lungs were extracted and stained for histopathology and examined for tissue damage, necrosis, apoptosis, and inflammatory cellular infiltration. Mean histopathology scores for each group were determined blindly as previously described³⁸ (n = 5 mice/treatment group). (c) Representative H&E-stained lung sections are shown.