Figure 6: Ablation of PLIN2 partially rescues β cell mass in Akita mice. | Scientific Reports

Figure 6: Ablation of PLIN2 partially rescues β cell mass in Akita mice.

From: PLIN2 is a Key Regulator of the Unfolded Protein Response and Endoplasmic Reticulum Stress Resolution in Pancreatic β Cells

Figure 6

(A) Hematoxylin and eosin staining of pancreas sections from 14-week-old mice. (B) Quantification of the islet area relative to the pancreas area. Total islet and pancreas area were counted from 6 sections per mouse (n = 5). (C) Insulin (green) and glucagon (red) immunofluorescence staining of pancreas sections from 14-week-old mice. Nuclei were stained with DAPI (blue). (D) Total pancreas insulin content of 14-week-old mice (n = 7). (E) Quantification of BrdU-positive β cells and (F) TUNEL-positive β cells. Percent BrdU-positive and TUNEL-positive β cells were calculated from 6 sections per mouse (n = 5). *p < 0.05. Scale bar = 50 μm.

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