Figure 6: Adipose precursor HO-1 deletion affects WAT function during obesity. | Scientific Reports

Figure 6: Adipose precursor HO-1 deletion affects WAT function during obesity.

From: HO-1 inhibits preadipocyte proliferation and differentiation at the onset of obesity via ROS dependent activation of Akt2

Figure 6

All mice (Hmox1fl/fl and Hmox1fl/flPdgfraCre34) were kept on HFD for 8 weeks. (A–D) Fasting circulating levels of glucose (A) and insulin (B) in obese mice. (C) HOMA-IR (n = 10–12). (D) Serum free fatty acids (NEFA) in obese mice (n = 10–12). (E) viWAT collagen content of Hmox1fl/fl and Hmox1fl/flPdgfraCre mice (n = 6). (F) Trichrome staining of visceral adipose tissue of Hmox1fl/fl and Hmox1fl/flPdgfraCre mice. Bar = 50 μm. (G) Isoprenaline stimulated lipolysis in viWAT pieces from Hmox1fl/fl and Hmox1fl/flPdgfraCre mice (n = 6). Results are mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001.

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