Figure 3: Voltage-gated calcium channel modulators affected SCO pattern in rat cardiomyocyte cultures. | Scientific Reports

Figure 3: Voltage-gated calcium channel modulators affected SCO pattern in rat cardiomyocyte cultures.

From: Modification of distinct ion channels differentially modulates Ca2+ dynamics in primary cultured rat ventricular cardiomyocytes

Figure 3

Representative traces of Bay K 8644-induced alterations in Ca2+ dynamics. Bay K 8644 produced irregularity on the SCO pattern with the occurrence of SCO bursts (A). Concentration-response relationship curves of Bay K 8644-induced decrease in frequency (B) and increase in amplitude (C) as well as prolongation in SCO/burst duration (D). Representative traces of nifedipine-induced alterations in Ca2+ dynamics (E). Concentration-response relationship curves of nifedipine-induced increase in frequency (F), decrease in amplitude (G) as well as shortening in SCO/burst duration (H). The experiments were repeated in three independent cultures each with four replicates.

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