Table 1 Comparison of potencies of ion channels modifiers tested on SCO responses and that from their respective targets.
Compounds | Targets | IC50/EC50 values (95% CI, μM) | Potency (μM) | Ref. | ||
|---|---|---|---|---|---|---|
Frequency | Amplitude | FWHM | ||||
Veratridine | VGSC | 5.79 (0.48–69.79) | — | 3.83 (0.029–506.8) | 4.76 | |
TTX | 0.86 (0.36–2.05) | — | — | 1.52 | ||
4-AP | Kv | — | 170 (48.1–598) | 88.7 (28.6–2745) | 100 | |
E-4031 | Kv11.1 | 0.041 (0.017–0.093) | — | 0.038 (0.012–0.121) | 0.099 | |
Bay K 8644 | LTCC | 0.019 (0.009–0.040) | 0.005 (0.002–0.009) | 0.046 (0.035–0.599) | 0.032 | |
Nifedipine | 0.053 (0.019–0.149) | 0.034 (0.019–0.063) | 0.071 (0.017–0.299) | 0.022 | ||
Ryanodine | RyR2 | 1.57 (0.37–6.76) | 3.60 (1.79–7.23) | 0.96 (0.14–6.52) | ~1 | |
FLA-365 | 0.93 (0.81–1.06) | — | — | 1–1.5 | ||
