Table 2 Markers that are shown to be associated with phenotype traits either at close to the claimed genome-wide significant p-value of ≤3.41 × 10−08 or at nominally significant p-value of ≤5.45 × 10−07.
From: Genetic risk variants for metabolic traits in Arab populations
Phenotype | Variant | Gene | Model | MAF | Beta $ | P-value $ | Beta # | P-value # | Bonferroni p-value | Benjamini–Hochberg FDR p-value |
|---|---|---|---|---|---|---|---|---|---|---|
A. Association at close to genome-wide significance of p-value ≤ 3.41E-08 | ||||||||||
HbA1c | chr15:40531386-rs12440118 | ZNF106 (W > R) | Recessive | 0.1059 | 2.006 | 7.07E-08 | 1.498 | 2.70E-05 | 0.003 | 0.0032 |
B. Associations at nominal significance of p-value ≤ 5.45E-07 | ||||||||||
rs7144734 | OTX2-AS1 (upstream) | Recessive | 0.2036 | 1.465 | 2.82E-07 | 1.361 | 4.31E-07 | 0.012 | 0.012 | |
TGL | rs17501809 | PLGRKT (intronic) | Recessive | 0.0593 | 1.807 | 1.04E-07 | 1.74 | 3.29E-07 | 0.0047 | 0.0016 |
TGL | rs11143005 | LOC105376072 (intronic) | Recessive | 0.2829 | 0.4196 | 4.03E-07 | 0.4225 | 3.21E-07 | 0.018 | 0.0030 |
TGL | chr12:101494770/rs10860880 | IGF1 (downstream) | Recessive | 0.05575 | 1.596 | 2.077–07 | 1.603 | 1.74E-07 | 0.0095 | 0.0019 |
TGL | rs900543 | THSD4, NR2E3 (intergenic/downstream to NR2E3) | Recessive | 0.08696 | 1.625 | 1.27E-07 | 1.607 | 1.67E-07 | 0.0058 | 0.0016 |
