Table 3 Effect of adjusting association tests for diabetes status and obesity status with markers identified at either close to the claimed genome-wide significant p-value of ≤3.41E-08 or at nominally significant p-value of ≤5.45E-07.
From: Genetic risk variants for metabolic traits in Arab populations
Marker and gene loci @ | Metabolic trait | Statistics after regular adjustment (RA) for age, sex, and the first 10 principal components and further adjustments for Diabetes medication (DM), Diabetes status (DS), and BMI as a surrogate for Obesity Status (OB) | |||||||
|---|---|---|---|---|---|---|---|---|---|
RA | RA + DM | RA + DS | RA + OB | ||||||
Beta | p-value | Beta | p-value | Beta | p-value | Beta | p-value | ||
chr15:40531386-rs12440118 ZNF106 (W > R) | HbA1c | 2.006 | 7.07E-08 | 1.50 | 2.705E-05 | 1.55 | 9.30E-05 | 1.96 | 1.17E-07 |
rs7144734 OTX2-AS1 (upstream) | FPG | 1.465 | 2.825E-07 | 1.36 | 4.312E-07 | 1.12 | 2.18E-06 | 1.51 | 8.8E-07 |
rs17501809 PLGRKT (intronic) | TGL | 1.807 | 1.043E-07 | 1.74 | 3.297E-07 | 1.72 | 3.50E-07 | 1.75 | 1.95E-07 |
rs11143005 LOC105376072 (intronic) | TGL | 0.420 | 4.035E-07 | 0.42 | 3.218E-07 | 0.42 | 2.27E-07 | 0.41 | 5.83E-07 |
chr12:101494770/rs10860880 IGF1 (downstream) | TGL | 1.596 | 2.077–07 | 1.60 | 1.746E-07 | 1.52 | 6.21E-07 | 1.53 | 5.15E-07 |
rs900543 THSD4, NR2E3 (intergenic/downstream to NR2E3) | TGL | 1.625 | 1.27E-07 | 1.61 | 1.67E-07 | 1.58 | 2.26E-07 | 1.59 | 1.849E-07 |
