Table 1 Properties and materials of each type of phantom in the simulations and experiments.

From: Small-window parametric imaging based on information entropy for ultrasound tissue characterization

 

Type no.

Objectives

Properties of the scatterers in the background

Additional scatterers or additive in the background

Simulations

Type-I

Simulating changes in the number density of scatterers

Point scatterers (RSC: 1) Number density of scatterers: 2, 4, 8, and 16 scatterers/mm2

Type-II

Simulating changes in the degree of variance in the echogenicity

Point scatterers (RSC: 1) Number density of scatterers: 16 scatterers/mm2

Point scatterers (RSC: 2, 4, 6, and 8) Number density of scatterers: 1 scatterers/mm2

Type-III

Simulating the tissue interface

Point scatterers (RSC: 1) Number density of scatterers: 16 scatterers/mm2

An embedded cylindrical object with point scatterers (RSC: 0.1) Number density of scatterers: 16 scatterers/mm2

Phantom experiments

Type-A

Simulating changes in the number density of scatterers

Glass beads Number density of scatterers: 2, 4, 8, and 16 scatterers/mm3

Type-B

Simulating changes in the degree of variance in the echogenicity

Graphite powder Scatterer concentration: 2 g in 200 mL water (>1000 scatterers/mm3)

Glass beads Scatterer concentration: 0.05, 0.1, and 0.3 g in 200 mL water

Type-C

Simulating the attenuation effect

Graphite powder Scatterer concentration: 2 g in 200 mL water (>1000 scatterers/mm3)

Soybean-oil lipid emulsions Lipid concentration: 0%, 5%, 10%, and 20%

Type-D

Simulating the tissue interface and exploring effects of frequency and focus

A tissue-mimicking breast phantom

  1. RSC: Relative scattering coefficients of scatterers in the simulations. The phantoms were constructed by boiling and cooling agar–water mixtures (dissolving 3 g of the agar powder into 200 mL of water) and adding different materials, including glass beads with diameters of 75 μm (Model 59200U, Supelco, Bellefonte, PA, USA), graphite powder with diameters < 20 μm (Model 282863, Sigma-Aldrich, St. Louis, MO, USA), and soybean-oil lipid emulsions (Intrafat, Nihon Pharmaceutical Industry, Osaka, Japan). In the simulations and phantom experiments, scatterers were randomly distributed.