Figure 3: VHL overexpression attenuated hepatic fibrosis in mice. | Scientific Reports

Figure 3: VHL overexpression attenuated hepatic fibrosis in mice.

From: Reduction of hepatic fibrosis by overexpression of von Hippel–Lindau protein in experimental models of chronic liver disease

Figure 3

Ad-Null or Ad-VHL were injected initially in Sham, BDL, Oil or CCl4 group (A,B and C), or injected in the established liver fibrosis models (D and E). (A) Representative liver sections of Sirius Red/Fast Green staining (original magnification, 100x) (B) Quantification of Sirius Red/Fast Green staining intensities (*p < 0.001). (C) Western blot analysis of VHL, HIF-1α, and HIF-2α expression, and the gels have been run under the same experimental conditions. (D) Representative liver sections of Sirius Red/Fast Green staining (original magnification, 100 x) (E) Quantification of Sirius Red/Fast Green staining intensities (*p < 0.001).

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