Figure 5: VHL overexpression attenuated hepatic fibrosis via HIF-1α and HIF-2α. | Scientific Reports

Figure 5: VHL overexpression attenuated hepatic fibrosis via HIF-1α and HIF-2α.

From: Reduction of hepatic fibrosis by overexpression of von Hippel–Lindau protein in experimental models of chronic liver disease

Figure 5

HIF-1α and HIF-2α were silenced by lentivirus vectors encoding siRNAs. (A) Representative liver sections of Sirius Red/Fast Green staining (original magnification, 100x). (B) Sirius Red/Fast Green staining intensities were quantified (*p < 0.001), and expressions of VHL, HIF-1α and HIF-2α were measured by Western blot analysis, and the gels have been run under the same experimental conditions. VHL, HIF-1α TM, and HIF-2α TM were overexpressed from adenovirus vectors. (C) Representative liver sections of Sirius Red/Fast Green staining (original magnification, 100x). (D) Sirius Red/Fast Green staining intensities were quantified (*p < 0.001), and expressions of VHL, HIF-1α and HIF-2α were measured by Western blot analysis, and the gels have been run under the same experimental conditions.

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