Table 1 Transcript levels of genes related to fibrosis and inflammation in mice.
Target gene | Sham | BDL | Oil | CCl4 | ||||
|---|---|---|---|---|---|---|---|---|
Ad-Null | Ad-VHL | Ad-Null | Ad-VHL | Ad-Null | Ad-VHL | Ad-Null | Ad-VHL | |
Glut1 | 1.00 ± 0.31 | 0.39 ± 0.19 | 39.58 ± 7.52* | 12.45 ± 3.88• | 1.00 ± 0.25 | 0.51 ± 0.20 | 6.78 ± 1.93* | 0.63 ± 0.35• |
LDHA | 1.00 ± 0.20 | 0.99 ± 0.33 | 9.26 ± 2.54* | 7.79 ± 2.51 | 1.00 ± 0.34 | 0.85 ± 0.34 | 6.35 ± 1.72* | 1.52 ± 0.43• |
PDK1 | 1.00 ± 0.26 | 0.94 ± 0.26 | 9.05 ± 3.07* | 2.48 ± 0.57• | 1.00 ± 0.23 | 0.80 ± 0.25 | 8.00 ± 1.78* | 3.00 ± 0.49• |
EPO | 1.00 ± 0.26 | 0.33 ± 0.11 | 40.76 ± 6.18* | 17.50 ± 4.02• | 1.00 ± 0.26 | 0.42 ± 0.07 | 28.67 ± 7.02* | 3.04 ± 0.84• |
Collagen-1α | 1.00 ± 0.32 | 0.48 ± 0.11 | 21.99 ± 1.61* | 7.01 ± 0.63• | 1.00 ± 0.19 | 0.80 ± 0.12 | 14.79 ± 1.54* | 5.30 ± 0.75• |
TGF-β1 | 1.00 ± 0.29 | 0.47 ± 0.11 | 14.36 ± 2.50* | 7.65 ± 1.62• | 1.00 ± 0.24 | 0.80 ± 0.20 | 6.38 ± 1.08* | 2.77 ± 0.64• |
TIMP-1 | 1.00 ± 0.32 | 0.73 ± 0.23 | 5.14 ± 0.57* | 1.73 ± 0.34• | 1.00 ± 0.32 | 0.93 ± 0.10 | 4.28 ± 0.58* | 1.51 ± 0.27• |
PAI-1 | 1.00 ± 0.25 | 0.72 ± 0.21 | 9.11 ± 1.54* | 4.73 ± 0.95• | 1.00 ± 0.22 | 0.78 ± 0.17 | 6.27 ± 0.74* | 2.60 ± 0.54• |
PDGF-B | 1.00 ± 0.20 | 0.77 ± 0.22 | 7.70 ± 1.20* | 2.87 ± 0.56• | 1.00 ± 0.27 | 0.98 ± 0.17 | 5.30 ± 0.67* | 1.97 ± 0.53• |
TNF-α | 1.00 ± 0.21 | 0.60 ± 0.12 | 15.20 ± 2.10* | 6.84 ± 1.58• | 1.00 ± 0.27 | 0.79 ± 0.15 | 4.46 ± 0.60* | 2.02 ± 0.39• |
MCP-1 | 1.00 ± 0.27 | 1.07 ± 0.24 | 7.14 ± 1.09* | 2.31 ± 0.41• | 1.00 ± 0.21 | 0.63 ± 0.12 | 4.31 ± 0.67* | 1.31 ± 0.22• |
MIP-1β | 1.00 ± 0.30 | 0.80 ± 0.31 | 11.69 ± 1.51* | 4.31 ± 0.95• | 1.00 ± 0.20 | 0.66 ± 0.18 | 6.17 ± 0.94* | 2.84 ± 0.38• |
MIP-2 | 1.00 ± 0.26 | 0.39 ± 0.08 | 8.81 ± 1.17* | 3.56 ± 0.71• | 1.00 ± 0.21 | 0.70 ± 0.16 | 7.73 ± 0.91* | 2.64 ± 0.52• |