Figure 3: The in vitro function of antibodies induced by PP-3copy-Aβ1-6-loop123. | Scientific Reports

Figure 3: The in vitro function of antibodies induced by PP-3copy-Aβ1-6-loop123.

From: Norovirus P particle-based active Aβ immunotherapy elicits sufficient immunogenicity and improves cognitive capacity in a mouse model of Alzheimer’s disease

Figure 3

The results are expressed as mean values ± SEM. (a) The Aβ aggregation inhibition assay. The serum antibodies from PP-3copy-Aβ1-6-loop123 vaccine immunized mice remarkably inhibited Aβ aggregation. *p = 0.0161, **p = 0.0014. (b) Aβ42 oligomer toxicity assay in PC12 cells. The antibodies induced by PP-3copy-Aβ1-6-loop123 treatment reversed the oligomer-induced toxicity in a concentration-dependent manner, *p = 0.0203.

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