Figure 4: The determination of Aβ42-specific antibody titers in APP/PS1 transgenic mice after PP-3copy-Aβ1-6-loop123 immunization. | Scientific Reports

Figure 4: The determination of Aβ42-specific antibody titers in APP/PS1 transgenic mice after PP-3copy-Aβ1-6-loop123 immunization.

From: Norovirus P particle-based active Aβ immunotherapy elicits sufficient immunogenicity and improves cognitive capacity in a mouse model of Alzheimer’s disease

Figure 4

Control groups received PBS, PP protein or Aβ42 peptide. The results are expressed as mean values ± SEM. (a) Grouping and immunization strategy for APP/PS1 transgenic mice. Aβ42 antibody titers after the forth immunization of PP-3copy-Aβ1-6-loop123 are detected in cohorts treated before the onset of AD (b), directly after the onset of AD (c), and long after the onset of AD (d). Absorbance values greater than twofold over the background were considered positive and are marked with *. (e) A comparison of average antibody titers and durations in the three age cohorts of mice immunized with PP-3copy-Aβ1-6-loop123.

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