Table 4 Comparison of mycobacterial SDR protein and cofactor surface area with other NAD- and NADP-dependent dehydrogenases.

From: Mycofactocin-associated mycobacterial dehydrogenases with non-exchangeable NAD cofactors

Species

PDB ID

Protein surface area (A2)

Cofactor total surface area (A2)

Cofactor solvent accessible surface area (A2)

M. abscessus

3S55

11,341

839

12

M. avium

3T7C

12,365

839

21

M. avium

3UVE

12,334

834

28

M. avium

4RGB

11,338

842

7

M. avium

3PXX

11,686

841

14

M. avium

5EJ2

11,728

852

26

M. paratuberculosis

3PGX

11,168

835

19

M. paratuberculosis

3SX2

11,320

842

7

M. paratuberculosis

3TSC

11,472

840

26

Average mycobacterial SDRs

 

11,639

840

18

Acholeplasma laidlawii

4NBT

10,890

842

99

Xanthobacter autotrophicus

4ITU

10,608

849

64

Homo sapiens

4CQM

11,373

837

72

Helicobactor pylori

4IIN

10,545

836

160

Bacillus sp. Sg-1

4NBU

11,127

840

48

Average NAD-bound dehydrogenases

 

11,015

841

89

Staphylococcus aureus

3SJ7

11,371

928

106

Listeria monocytogenes

4JRO

11,057

902

103

Synechococcus elongatus

4DMM

10,985

927

64

Brassica napus

1EDO

10,757

911

64

Escherichia coli

4IIU

11,223

916

74

Average NADP-bound dehydrogenases

 

11,079

916

82