Figure 2: Enzymes that significantly change between HBc and control cells. | Scientific Reports

Figure 2: Enzymes that significantly change between HBc and control cells.

From: Multi-omics analyses reveal metabolic alterations regulated by hepatitis B virus core protein in hepatocellular carcinoma cells

Figure 2

(A) Workflow of the SILAC-based proteomic identification process with forward and reverse labelling experiments. (B) The quality of SILAC labelling was determined by observing the normalized log2 ratio distribution of the differentially expressed proteins from the forward and reverse datasets. (C) The scatter plot displays the regulated proteins based on the protein expression ratios of HBc and control cells. (D) Functional enrichment analysis of differentially expressed proteins. The y-axis presents the functional categories identified in the GO analysis in terms of biological processes. The x-axis demonstrates the significance (p < 0.05). (E) KEGG annotation revealed the networks up-regulated by HBc. Large nodes represent metabolites within core regulatory networks. Enzymes are represented by small nodes. The results only showed pathways with p < 0.05 and cluster protein number ≥ 3.

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