Figure 3: Metabolic characterization of HBc cells. | Scientific Reports

Figure 3: Metabolic characterization of HBc cells.

From: Multi-omics analyses reveal metabolic alterations regulated by hepatitis B virus core protein in hepatocellular carcinoma cells

Figure 3

(A) Average 600 MHz 1H HRMAS NMR spectra of HBc and control cells. The region of δ5.0–9.5 was vertically expanded 4 times compared with δ0.5–4.5. The metabolite list is shown in Table S2. (B) Validated OPLS-DA scores and coefficient plots show the discriminations of the metabolic profiles of extracts of HBc cells (T) from control cells (W). The resonance peaks pointing upward indicate an increase of metabolites in HBc cells and vice versa. The colour of the peaks represents the correlation coefficient of a metabolite where the cut-off value of |r| was 0.847 (n = 10, p < 0.001). The detailed data are shown in Table S2. (C) Metabolites consumed by HBc and control cells. The data are shown as the mean ± standard deviation (SD), n = 1 0, t test, *p < 0.001. Notes: UDP-GlcA, UDP-glucose A; GPcholine, glycerophosphocholine. (D) The enrichment analysis displays the metabolic pathways regulated by HBc. (E) The integrated metabolic pathways were obtained from metabolomics and proteomics analyses.

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