Table 2 PD Model Parameters.

From: Predicting HIV Pre-exposure Prophylaxis Efficacy for Women using a Preclinical Pharmacokinetic-Pharmacodynamic In Vivo Model

Parameter

Dose (mg/kg)

Plasma (ng/ml)

FRT TFV (ng/g)

FRT TFVdp (fmol/g)

CVL (ng/ml)

E0

0.2502 [3.67]

0.2580 [13.24]

0.3151 [7.299]

0.2622 [7.405]

0.4016 [8.918]

EC50

38.7 [7.628]

259 [19.6]

4101 [21.18]

6.052e5 [22.75]

238.7 [51.53]

H

1.138 [10.4]

0.7449 [14.98]

NA

NA

NA

  1. All values are presented as mean (standard error [SE]). E0: baseline effect, EC50: concentration or dose reflecting half-maximal effect, H: Hill’s coefficient, FRT: female reproductive tract, TFV: tenofovir, TFVdp: tenofovir diphosphate, CVL: cervicovaginal lavage, and NA: not applicable.
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