Figure 11: Kidney-targeting shNLRP3 delivery into mice after induction of IgAN.
From: NLRP3 inflammasome: Pathogenic role and potential therapeutic target for IgA nephropathy
Urine albumin and Cr ratio on days 0, 7, 14, 28, and 36 (a), serum levels of BUN and Cr on day 36 (b). Kidney histopathology on day 36 [H&E staining] and F4/80+ macrophages and CD3+ T cells[IHC] (c), original magnification, 400x; arrow indicates periglomerular mononuclear leukocyte infiltration or positive staining. Renal lesion scores and scoring of stained cells in the glomerulus and periglomerular region on day 36 (d). The data show the mean ± SEM for results with 7 mice per group. *p < 0.05; **p < 0.01;***p < 0.005. #Not detectable. ns, no significant difference. gcs, glomerular cross section.
