Figure 4: NLRP3 inflammasome activation in IgA ICs-primed renal intrinsic cells.
From: NLRP3 inflammasome: Pathogenic role and potential therapeutic target for IgA nephropathy
Caspase-1 activity (a) and IL-1β secretion (b) measured by ELISA in glomerular primary MCs from untreated wild type or NLRP3 KO mice, which were incubated for 24 h with IgA ICs and 30 min ATP. Caspase-1 activity (c) and IL-1β secretion (d) measured by ELISA in renal TECs, which were incubated for 24 h with IgA ICs and 30 min ATP. The data are expressed as the mean ± SEM for three separate experiments. *p < 0.05. WT, wild type. ns, no significant difference. MCs, mesangial cells. TECs, tubular epithelial cells. IgA ICs, IgA immune complexes.
