Table 1 Serum levels of proinflammatory cytokines.

From: NLRP3 inflammasome: Pathogenic role and potential therapeutic target for IgA nephropathy

Conc. (pg/ml)

Day 14

Day 36

WT + saline

NLRP3 KO + saline

WT + IgAN

NLRP3 KO + IgAN

WT + saline

NLRP3 KO + saline

WT + IgAN

NLRP3 KO + IgAN

IL-1β

103.3 ± 7.2

110.6 ± 4.3

154.4 ± 5.2‡‡‡

106.7 ± 8.8***

107.4 ± 2.4

106.8 ± 3.0

183.5 ± 3.8‡‡‡

113.1 ± 9.5***

TNF-α

121.0 ± 5.8

118.7 ± 4.8

196.8 ± 26.1‡‡

163.6 ± 14.1‡

116.0 ± 13.4

120.0 ± 2.7

385.0 ± 80.5‡‡‡

193.5 ± 14.7‡‡*

IL-17A

6.2 ± 0.8

6.2 ± 0.7

6.1 ± 0.5

6.2 ± 0.9

6.0 ± 0.7

6.0 ± 0.5

18.9 ± 1.7‡‡

5.0 ± 0.2***

IL-4

3.3 ± 0.2

3.1 ± 0.3

3.2 ± 0.3

3.2 ± 0.2

3.2 ± 0.3

3.1 ± 0.5

3.3 ± 0.4

6.7 ± 0.6‡‡**

IFN-γ

5.0 ± 0.8

5.3 ± 0.7

8.6 ± 1.6

6.3 ± 0.7

5.1 ± 0.4

6.3 ± 0.1

16.8 ± 5.1‡

5.2 ± 1.8

  1. ELISA with serum samples taken from the mice on days 14 and 36 after the induction of IgAN (WT + IgAN mice; NLRP3 KO + IgAN mice) and respective saline controls (WT + saline mice; NLRP3 KO + saline mice). The data are expressed as the mean ± SEM for 7 mice per group. *p < 0.05, **p < 0.01, ***p < 0.005 compared to wild type mice. ‡p < 0.05, ‡‡p < 0.01, ‡‡‡p < 0.005 compared to saline control mice. WT, wild type.
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