Figure 2: Rer1 deletion in Purkinje cells causes motor deficits.
From: The sorting receptor Rer1 controls Purkinje cell function via voltage gated sodium channels
(a–c) Hind paws of mice of indicated age and genotype were stained with ink and the mice were allowed to walk across a paper. Base width and stride length were determined from the footprints. Displayed is the mean from 3 ctrl and 3 Rer1ΔPC 14 months (mo) old mice, 5 ctrl and 5 Rer1ΔPC 24 mo old mice ± SEM. (d) Mice of indicated age and genotype were placed on three consecutive days on a 1 cm broad, 1 m long beam and the time needed for crossing was determined. Displayed is the mean time of 4 ctrl and 4 Rer1ΔPC 4-6 mo, 4 ctrl and 5 Rer1ΔPC 8 mo, 6 ctrl and 6 Rer1ΔPC 10–11 mo old mice ± SEM. Ctrl refers to Rerfl/fl/cre−/− littermates.
