Figure 6: Reduced Nav1.6 expression at axon initial segments of Rer1-deficient Purkinje cells.
From: The sorting receptor Rer1 controls Purkinje cell function via voltage gated sodium channels
(a) Cerebellar sections of 34 days old Rer1ΔPC and control littermates mice (ctrl) were stained with antibodies against Nav1.6 and ankyrinG and imaged by confocal microscopy. 3 confocal sections were merged. Scalebar 10 μm. (b) Nav1.6 fluorescence intensities in the axon initial segment (AIS) were determined from sections of cerebella processed as in a). Displayed are the mean ± SEM of 243 AIS from 7 ctrl mice and 267 AIS from 8 Rer1ΔPC mice. a.u., arbitrary units. Ctrl refers to Rerfl/fl/cre−/− littermates.
