Table 5 Univariate and multivariate cox proportional hazard analysis for miR-27a rs895819 polymorphism.

Genotype	All GC	Death	MST^a (M)	Univariate		Multivariate^c
Genotype	All GC	Death	MST^a (M)	HR (95% CI)	P	HR (95% CI)	P
	n = 357	n = 89
AA	184	48	58.4^b	1 (Ref)		1 (Ref)
AG	148	36	58.8^b	0.89 (0.58–1.37)	0.597	0.84 (0.54–1.29)	0.415
GG	25	5	45.4^b	0.75 (0.30–1.88)	0.535	0.62 (0.25–1.57)	0.316
AG + GG VS. AA				0.87 (0.57–1.32)	0.510	0.80 (0.53–1.21)	0.294
GG VS. AG + AA				0.80 (0.32–1.97)	0.625	0.68 (0.27–1.67)	0.398
Subgroup analysis for TNM stage I–II
I–II	n = 171	n = 12
AA	91	11	67.0^b	1 (Ref)		1 (Ref)
AG	68	1	79.0^b	0.11 (0.01–0.87)	0.036	0.12 (0.02–0.91)	0.041
GG	12	0	NA	NA	NA	NA	NA
AG + GG VS. AA				0.10 (0.01–0.77)	0.027	0.10 (0.01–0.80)	0.030
GG VS. AG + AA				NA	NA	NA	NA
Subgroup analysis for Lymphatic metastasis (−)
Negative	n = 141	n = 12
AA	74	10	64.7^b	1 (Ref)		1 (Ref)
AG	58	2	76.9^b	0.22 (0.05–1.02)	0.054	0.25 (0.06–1.15)	0.076
GG	9	0	NA	NA	NA	NA	NA
AG + GG VS. AA				0.20 (0.05–0.93)	0.040	0.2 (0.05–1.03)	0.054
GG VS. AG + AA				NA	NA	NA	NA

Note: HR, hazard ratio; CI, confidence interval; ^aMST, median survival time (months). ^bwhen MST could not be calculated, mean survival time was provided. ^cMultivariate survival analysis was carried out by adding all the SNP variables to the clinicopathological parameters with P < 0.05 including TNM stage, lymphatic metastasis and depth of invasion. NA, not available.

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