Figure 4: Expression of claudin-5 protein is reduced in brain tissues from early- and late-symptomatic R6/2 mice.
From: Impairment of blood-brain barrier is an early event in R6/2 mouse model of Huntington Disease
Representative cropped immunoblottings and densitometric analysis of claudin-5 in cortical (A–C) and striatal (D–F) tissues isolated from pre- (A and D), early- (B and E) and late-HD (C and F) mice and age-matched WT littermates. Protein bands were visualized by ECL. Data are represented as mean ± SD, n = 4–5 for each group of mice. *p < 0.05; **p < 0.01 (Un-paired t-test).
